AbstractBackgroundPostpancreatitis diabetes mellitus (PPDM) is a common metabolic sequalae of acute and chronic pancreatitis. We conducted a cross‐sectional study to examine the proportion of PPDM among patients clinically diagnosed with type 2 diabetes (T2D) in Denmark and their clinical and biochemical characteristics.MethodsWe identified all past diagnoses of pancreatitis among patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort through linkage with national health registries. Using International Classification of Diseases, Tenth Revision codes we categorized patients as PPDM and further divided them into acute/chronic subtypes (PPDM‐A and PPDM‐C). We assessed PPDM prevalence and examined associations with clinical and biochemical parameters using log binomial or Poisson regression to calculate age‐/sex‐adjusted prevalence ratios (aPRs).ResultsAmong 5564 patients with a clinical diagnosis of T2D, 78 (1.4%) had PPDM. Compared to T2D, PPDM patients were more often underweight or normal weight (body mass index ≤25.0 kg/m²: aPR 2.3; 95% confidence interval [CI]: 1.6‐3.2) and had lower waist‐to‐hip ratio (≤0.95/≤0.80 in men/women: aPRs 1.8; 95% CI: 1.2‐2.7). PPDM patients had lower plasma amylase levels (<17 U/L: aPRs 2.2; 95% CI: 1.1‐4.3), higher insulin sensitivity (homeostatic model assessment 2S [HOMA2S] >63: aPR 2.0; 95% CI: 1.2‐3.2) and tended to have worse glycaemic control (HbA1c ≥8.0%: aPRs 1.4; 95% CI: 0.8‐2.4). PPDM‐A was largely indistinguishable from T2D, whereas PPDM‐C had impaired insulin secretion, higher insulin sensitivity, and worse glycemic control.ConclusionsThe proportion of PPDM among patients with clinically diagnosed T2D is ~1.5% in an everyday clinical care setting. Glucose metabolism of PPDM‐A is largely indistinguishable from T2D, whereas PPDM‐C differs in relation to insulin secretion and sensitivity.