Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile
Journal article published in 2023 by
Kate E. Dingle 
,
Jane Freeman,
Xavier Didelot ,
T. Phuong Quan ,
David W. Eyre,
Jeremy Swann,
William D. Spittal,
Emma V. Clark,
Keith A. Jolley,
A. Sarah Walker,
Mark H. Wilcox,
Derrick W. Crook
,
Jane Freeman,
Xavier Didelot ,
T. Phuong Quan ,
David W. Eyre,
Jeremy Swann,
William D. Spittal,
Emma V. Clark,
Keith A. Jolley,
A. Sarah Walker,
Mark H. Wilcox,
Derrick W. Crook
This paper is made freely available by the publisher.
Full text: Download
Data provided by 
Abstract
Fluoroquinolone and cephalosporin use in healthcare settings has triggered outbreaks of high-mortality, multidrug-resistant C. difficile infection. Here, we identify a mechanism associated with raised cephalosporin MICs in C. difficile comprising amino acid substitutions in two cell wall transpeptidase enzymes (penicillin binding proteins).