Published in
American Society for Microbiology, Journal of Virology, 24(95), 2021
DOI: 10.1128/jvi.01368-21
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Highly efficient SARS-CoV-2 infection of human cardiomyocytes: spike protein-mediated cell fusion and its inhibition
Journal article published in 2021 by
Chanakha K. Navaratnarajah,
David R. Pease,
Peter J. Halfmann 
,
Biruhalem Taye,
Alison Barkhymer,
Kyle G. Howell,
Jon E. Charlesworth,
Trace A. Christensen,
Yoshihiro Kawaoka,
Roberto Cattaneo,
Jay W. Schneider
,
Biruhalem Taye,
Alison Barkhymer,
Kyle G. Howell,
Jon E. Charlesworth,
Trace A. Christensen,
Yoshihiro Kawaoka,
Roberto Cattaneo,
Jay W. Schneider
This paper is made freely available by the publisher.
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Abstract
Cardiac complications frequently observed in COVID-19 patients are tentatively attributed to systemic inflammation and thrombosis, but viral replication has occasionally been confirmed in cardiac tissue autopsy materials. We developed an in vitro model of SARS-CoV-2 spread in myocardium using induced pluripotent stem cell-derived cardiomyocytes.