Preview Traditionally, historians date the beginning of the Modern Age as 1492, when Cristopher Columbus discovered America. This Italian sailor's innovative approach to reach the Indies was based on the idea of buscar el levante por el poniente, i.e. to fetch the east by the west. The recently published review by Franchini and Mannucci1 shows us that we are at the beginning of a modern age in the treatment of haemophilia, based on the same unconventional way to approach a problem. Haemophilia is defined as "an X-linked congenital bleeding disorder caused by a deficiency of coagulation factor VIII (FVIII) (in haemophilia A) or factor IX (FIX) (in haemophilia B). The deficiency is the result of mutations of the respective clotting factor genes". [ … ]