Metal–organic framework nanosheets (MONs) have recently emerged as a distinct class of 2D materials with programmable structures that make them useful in diverse applications. In this review, the breadth of applications that have so far been investigated are surveyed, thanks to the distinct combination of properties afforded by MONs. How: 1) The high surface areas and readily accessible active sites of MONs mean they have been exploited for a variety of heterogeneous, photo‐, and electro‐catalytic applications; 2) their diverse surface chemistry and wide range of optical and electronic responses have been harnessed for the sensing of small molecules, biological molecules, and ions; 3) MONs tunable optoelectronic properties and nanoscopic dimensions have enabled them to be harnessed in light harvesting and emission, energy storage, and other electronic devices; 4) the anisotropic structure and porous nature of MONs mean they have shown great promise in a variety of gas separation and water purification applications; are discussed. The aim is to draw links between the uses of MONs in these different applications in order to highlight the common opportunities and challenges presented by this promising class of nanomaterials.