INTRODUCTION. Medication non-adherence is one of the significant public health issue. Low adherence is one of the main reasons for the decrease therapeutic effect in patients with atrial fibrillation (AF), development of complications of AF, which leads to poor health outcomes and increased healthcare costs. Secondary prevention programs in cardiac rehabilitation may improve medication adherence in patients with AF. AIM. To assess the impact of secondary prevention methods on medication adherence in patients after catheter ablation (CA) performed for paroxysmal AF. MATERIALS AND METHODS. This is a prospective randomized controlled study with 3 parallel groups of patients with paroxysmal AF after CA (radiofrequency or cryoablation). Patients were randomized into 3 groups in 1:1:1 ratio. The 2 intervention groups received secondary prevention methods, including single-session in-person counseling and for 3 months of distant support (by phone in Group 1 or by e-mail in Group 2). Group 3 received usual care. Medication adherence was assessed using the 4-question scale Moriscos-Green. The medication adherence was evaluated at baseline and 12 months after CA. RESULTS AND DISCUSSION. A total of 135 patients aged 35 to 79 years were enrolled (mean age 57 9 years, 51,8 % men). At 1 year of follow-up patients from intervention group experienced significant improvement of medication adherence (p = 0,006 for Group 1 и 2) vs control. CONCLUSION. Secondary prevention methods with remote support improve the medication adherence in AF pts after CA which may positively affect on their health.