Published in
American Society for Microbiology, Microbiology Spectrum, 4(10), 2022
DOI: 10.1128/spectrum.01478-22
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BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis
Journal article published in 2022 by
Ivan Nombela,
Martine Michiels,
Dominique Van Looveren,
Lukas Marcelis 
,
Sara el Ashkar,
Siska Van Belle,
Anne Bruggemans ,
Thomas Tousseyn,
Jürg Schwaller,
Frauke Christ,
Rik Gijsbers,
Jan De Rijck,
Zeger Debyser
,
Sara el Ashkar,
Siska Van Belle,
Anne Bruggemans ,
Thomas Tousseyn,
Jürg Schwaller,
Frauke Christ,
Rik Gijsbers,
Jan De Rijck,
Zeger Debyser
This paper is made freely available by the publisher.
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Abstract
In this study, we have shown that the in vivo replication of murine leukemia virus happens independently of BET proteins, which are key host determinants involved in retroviral integration site selection. This finding opens a new research line in the discovery of alternative viral or host factors that may complement the dominant host factor.