The pyridazinone derivatives have diverse biological potential and are easily synthesized. Due to this, researchers and chemists have paid attention to the design and development of novel and effective bioactive compounds. The substituted pyridazines have shown a wide range of pharmacological activities, such as analgesic, anti-inflammatory, antibacterial, antifungal, anticonvulsant, antidepressant, antianxiety, antitubercular, anti-malarial, anticancer, anti-HIV, platelet inhibitory, hypotensive, cardiotonic, etc. In the current circumstances, it can be concluded that pyridazinone derivatives have great prospects, which remain to be revealed.