Published in
Royal Society of Chemistry, RSC Chemical Biology, 4(2), p. 1206-1220, 2021
DOI: 10.1039/d1cb00104c
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Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target
Journal article published in 2021 by
Faiza Javaid,
Camilla Pilotti,
Carlotta Camilli,
David Kallenberg 
,
Calise Bahou,
Jack Blackburn,
James R. Baker ,
John Greenwood,
Stephen E. Moss,
Vijay Chudasama
,
Calise Bahou,
Jack Blackburn,
James R. Baker ,
John Greenwood,
Stephen E. Moss,
Vijay Chudasama
This paper is made freely available by the publisher.
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Abstract
LRG1 is present abundantly in the microenvironment of many tumours. LRG1 targeting through the reported non-internalising ADC presents a novel and effective proof-of-concept en route to improving the efficacy of cancer therapeutics.