AbstractLandfalling tropical cyclones (LTCs) are the most devastating disaster to affect the U.S., while the demonstration of skillful subseasonal (between 10 days and one season) prediction of LTCs is less promising. Understanding the mechanisms governing the subseasonal variation of TC activity is fundamental to improving its forecast, which is of critical interest to decision-makers and the insurance industry. This work reveals three localized atmospheric circulation modes with significant 10–30 days subseasonal variations: Piedmont Oscillation (PO), Great America Dipole (GAD), and the Subtropical High ridge (SHR) modes. These modes strongly modulate precipitation, TC genesis, intensity, track, and landfall near the U.S. coast. Compared to their strong negative phases, the U.S. East Coast has 19 times more LTCs during the strong positive phases of PO, and the Gulf Coast experiences 4–12 times more frequent LTCs during the positive phases of GAD and SHR. Results from the GFDL SPEAR model show a skillful prediction of 13, 9, and 22 days for these three modes, respectively. Our findings are expected to benefit the prediction of LTCs on weather timescale and also suggest opportunities exist for subseasonal predictions of LTCs and their associated heavy rainfalls.