Published in
American Society for Microbiology, Journal of Clinical Microbiology, 12(59), 2021
DOI: 10.1128/jcm.01236-21
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High Prevalence of Coinfecting Enteropathogens in Suspected Rotavirus Vaccine Breakthrough Cases
Journal article published in 2021 by
Ceren Simsek 
,
Mandy Bloemen,
Daan Jansen ,
Leen Beller,
Patrick Descheemaeker,
Marijke Reynders,
Marc Van Ranst,
Jelle Matthijnssens
,
Mandy Bloemen,
Daan Jansen ,
Leen Beller,
Patrick Descheemaeker,
Marijke Reynders,
Marc Van Ranst,
Jelle Matthijnssens
This paper is made freely available by the publisher.
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Abstract
Despite the global use of rotavirus vaccines, vaccine breakthrough cases remain a pediatric health problem. In this study, we investigated suspected rotavirus vaccine breakthrough cases using next-generation sequencing (NGS)-based viral metagenomics ( n = 102) and a panel of semiquantitative reverse transcription-PCR (RT-qPCR) ( n = 92) targeting known enteric pathogens.