Published in
American Society for Microbiology, Journal of Virology, 6(97), 2023
DOI: 10.1128/jvi.00400-23
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The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes
Journal article published in 2023 by
Hella Schwanke 
,
Vladimir Gonçalves Magalhães ,
Stefan Schmelz ,
Emanuel Wyler ,
Thomas Hennig ,
Thomas Günther ,
Adam Grundhoff,
Lars Dölken,
Markus Landthaler ,
Marco van Ham,
Lothar Jänsch,
Konrad Büssow ,
Joop van den Heuvel ,
Wulf Blankenfeldt ,
Caroline C. Friedel
and other authors.
,
Vladimir Gonçalves Magalhães ,
Stefan Schmelz ,
Emanuel Wyler ,
Thomas Hennig ,
Thomas Günther ,
Adam Grundhoff,
Lars Dölken,
Markus Landthaler ,
Marco van Ham,
Lothar Jänsch,
Konrad Büssow ,
Joop van den Heuvel ,
Wulf Blankenfeldt ,
Caroline C. Friedel
and other authors.
This paper is made freely available by the publisher.
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Abstract
Replication of the ubiquitous human cytomegalovirus (HCMV) in healthy individuals mostly goes unnoticed but can impair fetal development or cause life-threatening symptoms in immunosuppressed or -deficient patients. Like other herpesviruses, CMV extensively manipulates its hosts and establishes lifelong latent infections.