Published in
Royal Society of Chemistry, Chemical Science, 41(14), p. 11447-11455, 2023
DOI: 10.1039/d3sc02802j
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Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide
Journal article published in 2023 by
Inês C. B. Martins 
,
Anders S. Larsen,
Anders Ø. Madsen ,
Olivia Aalling Frederiksen,
Alexandra Correia,
Kirsten M. Ø. Jensen,
Henrik S. Jeppesen ,
Thomas Rades
,
Anders S. Larsen,
Anders Ø. Madsen ,
Olivia Aalling Frederiksen,
Alexandra Correia,
Kirsten M. Ø. Jensen,
Henrik S. Jeppesen ,
Thomas Rades
This paper is made freely available by the publisher.
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Abstract
Three polyamorphs of hydrochlorothiazide with distinct physicochemical properties were discovered. MD simulations show different dihedral angle distributions in polyamorphs I and II. Polyamorphs I and III were converted into polyamorph II.