Published in
American Society for Microbiology, Microbiology Spectrum, 3(10), 2022
DOI: 10.1128/spectrum.00916-22
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Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression
Journal article published in 2022 by
Zachary N. Phillips 
,
Claudia Trappetti,
Annelies Van Den Bergh,
Gael Martin,
Ainslie Calcutt,
Victoria Ozberk,
Patrice Guillon,
Manisha Pandey,
Mark von Itzstein ,
W. Edward Swords ,
James C. Paton ,
Michael P. Jennings ,
John M. Atack
,
Claudia Trappetti,
Annelies Van Den Bergh,
Gael Martin,
Ainslie Calcutt,
Victoria Ozberk,
Patrice Guillon,
Manisha Pandey,
Mark von Itzstein ,
W. Edward Swords ,
James C. Paton ,
Michael P. Jennings ,
John M. Atack
This paper is made freely available by the publisher.
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Abstract
S. pneumoniae is the world’s foremost bacterial pathogen. S. pneumoniae encodes a phasevarion (phase-variable regulon), that results in differential expression of multiple genes. Previous work demonstrated that the pneumococcal SpnIII phasevarion switches between six different expression states, generating six unique phenotypic variants in a pneumococcal population.