AbstractStrongyloidiasis control is associated with a Th2 immune response. However, alcohol ingestion plays an important role in modulating the immune system. The aim of this study is to evaluate the occurrence of Strongyloides stercoralis infection in alcoholic patients, the levels of circulating cytokines (IFN‐γ, IL‐2, IL‐4, IL‐5, IL‐10, IL‐15 and IL‐17), and its correlation with modulation of parasitic load in alcoholic individuals infected with S. stercoralis. A total of 336 alcoholic patients, treated at the Alcoholic Care and Treatment Center were included in this study. The cytokine levels were measured by a commercial ELISA in 80 sera divided into four groups with 20 individuals each: alcoholics infected (ASs+) and not infected (ASs‐) with S. stercoralis and non‐alcoholics infected (NASs+) and not infected (NASs‐) with the helminth. S. stercoralis frequency in alcoholic patients was 16.1% (54/336). The parasitic load varied from 1 to 546 larvae/g of faeces, median and interquartile range (IQR) of 9 and 1.0–62.5 larvae/g of faeces, while in non‐alcoholic individuals the parasitic load was less than 10 larvae/g of faeces. Levels of circulating IL‐4 were significantly higher in ASs+ when compared with NASs‐ group (p < .05). An inverse correlation between serum levels of IFN‐γ and parasitic load in alcoholic patients infected with S. stercoralis was observed (r = −601; p < 0.01). These results suggest that modulation of IFN‐γ production occurs in alcoholic individuals with high parasitic burden.