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American Physiological Society, American Journal of Physiology - Renal Physiology, 4(325), p. F426-F435, 2023

DOI: 10.1152/ajprenal.00108.2023

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Amiloride evokes significant natriuresis and weight loss in kidney transplant recipients with and without albuminuria

Journal article published in 2023 by Gitte Rye Hinrichs ORCID, Jette Rude Nielsen, Henrik Birn ORCID, Claus Bistrup ORCID, Boye Lagerbon Jensen ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Amiloride has a significant natriuretic effect in kidney transplant recipients (KTRs) that relates to urinary albumin excretion. The epithelial Na+ channel may be a relevant direct pharmacological target to counter Na+ retention and hypertension in KTRs. Epithelial Na+ channel blockers should be further investigated as a mean to mitigate Na+ and water retention and to potentially obtain optimal blood pressure control in KTRs.