AbstractBackgroundIn view of limited evidence that specifically addresses vaccine effectiveness (VE) in the older population, this study aims to evaluate the real-world effectiveness of BNT162b2 and CoronaVac in older adults during the Omicron BA.2 outbreak.MethodsThis case–control study analyzed data available between January and March 2022 from the electronic health databases in Hong Kong and enrolled individuals aged 60 or above. Each case was matched with up to 10 controls by age, sex, index date and Charlson Comorbidity Index for the four outcomes (COVID-19 infection, COVID-19-related hospitalization, severe complications, and all-cause mortality) independently. Conditional logistic regression was conducted to evaluate VE of BNT162b2 and CoronaVac against COVID-19-related outcomes within 28 days after COVID-19 infection among participants stratified by age groups (60–79, ≥80 years old).ResultsA dose–response relationship between the number of vaccine doses received and protection against severe or fatal disease was observed. Highest VE (95% CI) against COVID-19 infection was observed in individuals aged ≥80 who received three doses of BNT162b2 [75.5% (73.1–77.7%)] or three doses of CoronaVac [53.9% (51.0–56.5%)] compared to those in the younger age group who received three doses of BNT162b2 [51.1% (49.9–52.4%)] or three doses of CoronaVac [2.0% (−0.1–4.1%)]. VE (95% CI) was higher for other outcomes, reaching 91.9% (89.4–93.8%) and 86.7% (84.3–88.8%) against COVID-19-related hospitalization; 85.8% (61.2–94.8%) and 89.8% (72.4–96.3%) against COVID-19-related severe complications; and 96.4% (92.9–98.2%) and 95.0% (92.1–96.8%) against COVID-19-related mortality after three doses of BNT162b2 and CoronaVac in older vaccine recipients, respectively. A similar dose–response relationship was established in younger vaccine recipients and after stratification by sex and Charlson Comorbidity Index.ConclusionBoth BNT162b2 and CoronaVac vaccination were effective in protecting older adults against COVID-19 infection and COVID-19-related severe outcomes amidst the Omicron BA.2 pandemic, and VE increased further with the third dose.