AbstractThe dynamics of the Alps and surrounding regions is still not completely understood, partly because of a non‐unique interpretation of its upper‐mantle architecture. In particular, it is unclear if interpreted slabs are consistent with the observed surface deformation and topography. We derive three end‐member scenarios of lithospheric thickness and slab geometries by clustering available shear‐wave tomography models into a statistical ensemble. We use these scenarios as input for geodynamic simulations and compare modeled topography, surface velocities and mantle flow to observations. We found that a slab detached beneath the Alps, but attached beneath the Northern Apennines captures first‐order patterns in topography and vertical surface velocities and can provide a causative explanation for the observed seismicity.