The biomass of vinification results in up to 20% by-products (seeds, skins, pulp, and/or stems) that can be used in the production of diverse functional food, nutraceutical, pharmaceutical, and cosmetic ingredients, mainly due to their high polyphenol content. Conventional polyphenol extraction techniques are based on the use of solvents that are harmful to health and to the environment, creating a demand for sustainable complementary initiatives that mitigate part of the environmental effects and offer consumer safety. Current advances in these technologies allow for the recovery of valuable antioxidants from winemaking by-products free of hazardous solvents, biocompatible, and in compliance with international sustainable development guidelines. Nanotechnology has gained prominence in the development of green technologies to reduce or eliminate toxic agents and improve the stability and bioavailability of waste polyphenols. These efforts have led to the application of bioactive compounds from wine by-products in the development of more efficacious sunscreens, as a skin protection approach, and improvements in the antioxidant effectiveness of nanocarriers with potential use in the promotion of cutaneous health. We aimed to present different extraction and encapsulation technologies for biologically active compounds from wine by-products (Vitis vinifera L.). We also focused on a particular application of such compounds towards the development of value-added skin protection products aligned with a sustainable circular economy.