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Wiley, Angewandte Chemie, 8(135), 2023

DOI: 10.1002/ange.202217210

Wiley, Angewandte Chemie International Edition, 8(62), 2023

DOI: 10.1002/anie.202217210

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Mechanisms and Synthetic Strategies in Visible Light‐Driven [2+2]‐Heterocycloadditions

Journal article published in 2023 by Pietro Franceschi, Sara Cuadros ORCID, Giulio Goti ORCID, Luca Dell'Amico ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

AbstractThe synthesis of four membered heterocycles usually requires multi‐step procedures and prefunctionalized reactants. A straightforward alternative is the photochemical [2+2]‐heterocycloaddition between an alkene and a carbonyl derivative, conventionally based on the photoexcitation of this latter. However, this approach is limited by the absorption profile of the carbonyl, requiring in most of the cases the use of high‐energy UV‐light, that often results in undesired side reactions and/or the degradation of the reaction components. The development of new and milder visible light‐driven [2+2]‐heterocycloadditions is, therefore, highly desirable. In this Review, we highlight the most relevant achievements in the development of [2+2]‐heterocycloadditions promoted by visible light, with a particular emphasis on the involved reaction mechanisms. The open challenges will also be discussed, suggesting new possible evolutions, and stimulating new methodological developments in the field.