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Oxford University Press, Open Forum Infectious Diseases, 5(9), 2022

DOI: 10.1093/ofid/ofac179

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Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission.

Journal article published in 2022 by Libby van Tonder, J. Kenneth Baillie, Shona C. Moore, Gail Carson, Ana da Silva Filipe, Beatrice Alex, Peter Young, Benjamin Bach, Wendy S. Barclay, Debby Bogaert, Meera Chand, Katharine A. Relph, Lance C. W. Turtle, Graham S. Cooke, Maria Zambon and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).