Published in

National Academy of Sciences, Proceedings of the National Academy of Sciences, 18(118), 2021

DOI: 10.1073/pnas.2016855118

Links

Tools

Export citation

Search in Google Scholar

Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures

Journal article published in 2021 by Kartika Padhan ORCID, Eirini Moysi, Alessandra Noto ORCID, Alexander Chassiakos, Khader Ghneim, Maria Maddalena Perra ORCID, Sanjana Shah, Vasilis Papaioannou, Giulia Fabozzi, David R. Ambrozak, Antigoni Poultsidi ORCID, Maria Ioannou ORCID, Craig Fenwick ORCID, Samuel Darko ORCID, Daniel C. Douek and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

SignificanceWe characterized the heterogeneity of human TFH cells at a cellular, molecular, functional, and positional level and revealed possible mechanistic links between relevant determinants of this heterogeneity. Linking the topology with specific molecular profile and function is a key aspect in the understanding of the role of particular TFH cell subsets in the pathogenesis of relevant diseases and the delivery of optimal help to GC B cells for the development of potent neutralizing antibodies.