Degradation and heat generation are among the major concerns when treating Lithium-ion batteries’ health and performance parameters. Due to the high correlation between the battery’s degradation, autonomy and heat generation to the cell’s operational temperature, the Battery Thermal Management System plays a key role in maximizing the battery’s health. Given the fact that the ideal temperature for degradation minimization usually does not match the ideal temperature for heat generation minimization, the BTMS must manage these phenomena in order to maximize the battery’s lifespan. This work presents a new definition of the discharge operation point of a lithium-ion battery based on degradation, autonomy and heat generation. Two cells of different electrodes formulation were modeled and evaluated in a case study. The results demonstrated a 50% improvement on total useful battery cycles in best-case scenarios.