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Royal Society of Chemistry, RSC Chemical Biology, 4(2), p. 1239-1248, 2021

DOI: 10.1039/d1cb00079a

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Deciphering the substrate recognition mechanisms of the heparan sulfate 3-O-sulfotransferase-3

Journal article published in 2021 by Rylee Wander ORCID, Andrea M. Kaminski ORCID, Yongmei Xu, Vijayakanth Pagadala ORCID, Juno M. Krahn, Truong Quang Pham, Jian Liu ORCID, Lars C. Pedersen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Co-crystallization and biochemical analyses with structurally defined oligosaccharides show the low reactivity of HS 3-OST-3 toward 6-O-sulfated substrates is due to inhibition of enzyme activity by 6-O-sulfated oligosaccharides.