A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis
Journal article published in 2023 by
Joanne M. O’Hara,
Shoko Wakabayashi,
Noman Siddiqi,
Elaine Cheung,
Gregory H. Babunovic,
Claudette M. Thompson,
Ying-Jie Lu,
Eric J. Rubin 
,
Richard Malley ,
Fan Zhang
,
Richard Malley ,
Fan Zhang
This paper is made freely available by the publisher.
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Abstract
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. Here, we evaluate a novel vaccine which induces a broad immune response to Mycobacterium tuberculosis including robust antibody responses and long-lived systemic and tissue-resident memory Th1, Th17, and cytotoxic CD4 + and CD8 + T cells.