Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis
Journal article published in 2023 by
Francesca G. Tomasi 
,
Jessica T. P. Schweber,
Satoshi Kimura ,
Junhao Zhu,
Laura A. T. Cleghorn ,
Susan H. Davis,
Simon R. Green,
Matthew K. Waldor,
Eric J. Rubin
,
Jessica T. P. Schweber,
Satoshi Kimura ,
Junhao Zhu,
Laura A. T. Cleghorn ,
Susan H. Davis,
Simon R. Green,
Matthew K. Waldor,
Eric J. Rubin
This paper is made freely available by the publisher.
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Abstract
Peptidyl tRNA hydrolase (Pth) is an enzyme that cuts unfinished peptides off tRNA that has been prematurely released from a stalled ribosome. Pth is essential in nearly all bacteria, including the pathogen Mycobacterium tuberculosis (Mtb), but it has not been clear why.