Dissemin is shutting down on January 1st, 2025

Published in

Oxford University Press, Open Forum Infectious Diseases, 6(8), 2021

DOI: 10.1093/ofid/ofab256

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IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis

Journal article published in 2021 by Isaiah R. Turnbull, Monty B. Mazer, Mark H. Hoofnagle, John P. Kirby, Jennifer M. Leonard, Carlos Mejia-Chew, Andrej Spec ORCID, Jane Blood, Sydney M. Miles, Eric M. Ransom, Robert F. Potter, Joseph P. Gaut, Kenneth E. Remy ORCID, Richard S. Hotchkiss
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Abstract A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.