Wiley, Journal of Heterocyclic Chemistry, 8(59), p. 1417-1429, 2022
DOI: 10.1002/jhet.4483
Full text: Unavailable
AbstractHerein, we report the multicomponent synthesis of pyrido[2,3‐d]pyrimidine derivatives from 6‐aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst‐free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work‐up procedure, and a greener approach compared with other methods reported in the literature.