Published in
American Society for Microbiology, Journal of Virology, 15(95), 2021
DOI: 10.1128/jvi.02425-20
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Selective BCL-X <sub>L</sub> Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs
Journal article published in 2021 by
Yanqin Ren,
Szu Han Huang,
Amanda B. Macedo,
Adam R. Ward,
Winiffer D. Conce Alberto,
Thais Klevorn,
Louise Leyre,
Dennis C. Copertino,
Talia M. Mota,
Dora Chan,
Ronald Truong,
Thomas Rohwetter,
Paul Zumbo,
Friederike Dündar 
,
Doron Betel
and other authors.
,
Doron Betel
and other authors.
This paper is made freely available by the publisher.
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Abstract
Although antiretroviral therapy (ART) has transformed HIV infection into a manageable chronic condition, there is no safe or scalable cure. HIV persists in “reservoirs” of infected cells that reinitiate disease progression if ART is interrupted.