AbstractIntelligent monitoring human physiological information in real time raises the demand for skin‐integrated electronics, as which is a flexible format and can be mounted onto the curved human skin for noninvasive healthcare monitoring. The biofluid such as sweat from skin contains abundant biomarkers reflecting body health conditions. Here, a skin‐integrated sweat monitor with six biosensors embedded for the detection of NH₄⁺, Na⁺, glucose, pH, skin impedance, and surface temperature is described, which could decode the information in the fresh sweat generated during exercising. Furthermore, the system also includes an innovative safety warning mechanism, which is based on a miniaturized actuator to provide mechanical stimuli, and coupled with six changeable colors light emitting diodes corresponding to the six biosensors for providing simultaneous safety alarming to users. The self‐developed microfluidics system with a hydrophilic surface allows to enhance the sweat collection rate. Meanwhile, microfluidic filters can reduce the interruption of skin debris during biosignal monitoring. These state‐of‐art biosensors can real‐time monitor health related signals with excellent linearity and specificity. The skin‐integrated sweat monitor system exhibits a great potential in human healthcare monitoring and medical treatment.