Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients
Journal article published in 2022 by
Angela Gomez-Simmonds 
,
Medini K. Annavajhala ,
Maria Patricia Nunez,
Nenad Macesic,
Heekuk Park,
Anne-Catrin Uhlemann
,
Medini K. Annavajhala ,
Maria Patricia Nunez,
Nenad Macesic,
Heekuk Park,
Anne-Catrin Uhlemann
This paper is made freely available by the publisher.
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Abstract
Liver transplant (LT) recipients have high rates of Clostridioides difficile infection (CDI), which has been associated with poor outcomes, including graft-related complications and mortality, in prior studies. Susceptibility to CDI is known to increase following perturbations in intestinal commensal bacteria that enable germination of C. difficile spores and bacterial overgrowth.