AbstractSixty years after the discovery of ¹⁵⁴Dy, the half-life of this pure alpha-emitter was re-measured. ¹⁵⁴Dy was radiochemically separated from proton-irradiated tantalum samples. Sector field- and multicollector-inductively coupled plasma mass spectrometry were used to determine the amount of ¹⁵⁴Dy retrieved. The disintegration rate of the radio-lanthanide was measured by means of α-spectrometry. The half-life value was determined as (1.40 ± 0.08)∙10⁶ y, with an uncertainty reduced by a factor of ~ 10 compared to the currently adopted value of (3.0 ± 1.5)∙10⁶ y. This precise half-life value is useful for the the correct testing and evaluation of p-process nucleosynthetic models using ¹⁵⁴Dy as a seed nucleus or as a reaction product, as well as for the safe disposal of irradiated target material from accelerator driven facilities. As a first application of the half-life value determined in this work, the excitation functions for the production of ¹⁵⁴Dy in proton-irradiated Ta, Pb, and W targets were re-evaluated, which are now in agreement with theoretical calculations.