Published in
American Society for Microbiology, Journal of Virology, 2(97), 2023
DOI: 10.1128/jvi.01945-22
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Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
Journal article published in 2023 by
Brian Montoya 
,
Cory J. Knudson ,
Carolina R. Melo-Silva ,
Lingjuan Tang ,
Samita Kafle,
Luis J. Sigal
,
Cory J. Knudson ,
Carolina R. Melo-Silva ,
Lingjuan Tang ,
Samita Kafle,
Luis J. Sigal
This paper is made freely available by the publisher.
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Abstract
The molecules RIPK3 and MLKL are required for necroptotic cell death, which is widely thought of as an antiviral mechanism. Here we show that C57BL/6 (B6) mice deficient in RIPK3 or MLKL are as susceptible as WT B6 mice to ECTV lethality after a low-dose intraperitoneal infection and are as resistant as WT B6 mice after ECTV infection through the natural footpad route.