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MDPI, Molecules, 9(26), p. 2650, 2021

DOI: 10.3390/molecules26092650

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Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution

Journal article published in 2021 by Vusani Mandiwana, Lonji Kalombo, Rose Hayeshi, Jan Rijn Zeevaart ORCID, Thomas Ebenhan ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.