Clustering and erratic movement patterns of syringe-injected versus mosquito-inoculated malaria sporozoites underlie decreased infectivity
Journal article published in 2020 by
C. M. de Korne 
,
B. M. F. Winkel,
M. N. van Oosterom,
S. Chevalley Maurel,
H. M. Houwing,
J. C. Sijtsma,
S. Azargoshasb,
E. Baalbergen,
B. M. D. Franke Fayard,
F. W. B. van Leeuwen,
M. Roestenberg
,
B. M. F. Winkel,
M. N. van Oosterom,
S. Chevalley Maurel,
H. M. Houwing,
J. C. Sijtsma,
S. Azargoshasb,
E. Baalbergen,
B. M. D. Franke Fayard,
F. W. B. van Leeuwen,
M. Roestenberg
This paper is made freely available by the publisher.
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Abstract
Malaria still causes a major burden on global health and the economy. The efficacy of live, attenuated malaria sporozoites as vaccine candidates critically depends on their ability to migrate to and infect the host liver.