Abstract Bovine lumpy skin disease is a viral disease that causes significant economic damage to dairy and beef cattle breeding. Its prevention is based on the vaccination of animals. The use of vaccines, on the one hand, allows to control the spread of the disease, on the other hand, to cause various complications in animals in the form of embryonic mortality and abortions. The use of immunostimulants is recommended to increase the effectiveness of vaccination of animals,. One of which may be a specific transfer factor. Transfer factor is a complex of simple and complex proteins that are able to sensitize the cells of the animal’s immune system to the antigen, accelerate the immunological response and prolong the effect of the vaccine, according to some data, up to one year. Its effect in vaccinating animals against lumpy skin disease has not been studied. The aim of the work was to assess the impact of a specific transfer factor on some indicators of the clinical status of animals during their vaccination against lumpy skin disease. During the study, it was found that vaccination of animals does not lead to an increase in body temperature above the physiological norm, viral antigens are not secreted through the genital tract of females. Vaccination of animals leads to liver dysfunction. This is manifested by an increase in the activity of alkaline phosphatase by 6%, the content of bilirubin by 39.3%, cholesterol by 19.9%. The use of transfer factor and the preparation Isidivit simultaneously with vaccinations, which has a hepatoprotective effect due to the content of vitamin E, allows to reduce the toxic effect of the vaccine on the liver. At the same time, the activity of alkaline phosphatase in comparison with the initial value decreases by 15.1%, the content of bilirubin increased only by 8.4%, and the content of cholesterol decreased by 5.5%.