Relevance. High milk productivity of cows after calving is the cause of liver damage in the form of hepatosis and premature retirement of animals. In such cases, pathoanatomical examination of the liver reveals simultaneously disorders in the form of protein and fatty dystrophies with subsequent destruction of cellsand circulatory disorders. Hepatoses can also cause such postpartum complications in cows as retention of placenta .Methods. For the prevention of hepatosis, the drug "Ovostim-ct" is proposed, which contains cytotoxic serums against the tissues of the liver, ovary, spleen and muscle. In order to prevent liver damage and postpartum retention of placenta , the drug is used 1–1.5 months before calving at a dose of 1 ml per 100 kg of live weight subcutaneously or intramuscularly.Results. The use of the hepatoprotector has reduced the number of cases of hepatosis and retention of placenta in cows after calving. Also, “Ovostim-ct” had a beneficial effect on the biochemical parameters of the blood serum of cows: there was an increase in the concentration in the bloodof total protein by 6.7%, albumin — by 15.6% and glucose — by 45.8%.