Relevance. Lumpy skin disease of cattle is a viral disease that causes significant economic damage to dairy and beef cattle breeding. The basis of its prevention is the vaccination of animals. The use of vaccines, on the one hand, allows you to control the spread of the disease, on the other hand, cause various complications in animals in the form of embryonic death and abortion. To increase the effectiveness of animal vaccination, the use of immunostimulants is recommended, one of which may be a specific transfer factor. The transfer factor is a complex of simple and complex proteins that are able to sensitize the cells of the animal’s immune system to the antigen, accelerate the immunological response and prolong the effect of the vaccine, according to some data, up to one year. Its effect in vaccinating animals against lumpy skin disease has not been studied. The aim of the work was to evaluate the impact of a specific transfer factor on some indicators of the clinical status of animals during their vaccination against lumpy skin disease. The study found that vaccination of animals does not lead to an increase in body temperature above the physiological norm, viral antigens are not excreted through the genital tract of females.Methodology. Vaccination of animals leads to impaired liver function. This is manifested by an increase in the activity of alkaline phosphatase by 6%, in the content of bilirubin — by 39.3%, of cholesterol — by 19.9%.Results. The use simultaneously with vaccinations of the transfer factor and the drug Isidivit, which has a hepatoprotective effect due to the content of vitamin E, can reduce the toxic effect of the vaccine on the liver. The activity of alkaline phosphatase compared with the initial value decreases by 15.1%, the content of bilirubin increased by only 8.4%, and the cholesterol content decreased by 5.5%.