Soil salinity has emerged as a global threat to sustainability of farming systems by deteriorating the quality and productivity of crops particularly in the coastal regions of the world. Although, as a C4 plant, maize (Zea mays L.) has ability to tolerate a medium level of salinity; but initial growth stages of maize are sensitive to salinity stress. Therefore, it is crucial to expand our understanding pertaining to maize response to salt stress and tolerance mechanisms for devising approaches to enhance maize adaptability in saline environments. Moreover, maize crop undergoes several physiological changes and adapts some mechanism to overcome the salinity stress. Different mitigation strategies like application of chemicals, plant growth-promoting hormones, and use of genetic and molecular techniques are used to manage salinity and may ensure crop productivity under changing climate. This chapter aimed to assess the recent advancement pertaining to salinity stress influence on the physio-biochemical processes in maize and to draw the relationship between yield components and salinity stress. In addition, current study also highlights research gaps by focusing the seed enhancement techniques, phytohormones exogenous application and genetic improvement of maize under soil salinity.