Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada
Journal article published in 2021 by
Calvin P. Sjaarda 
,
Jennifer L. Guthrie,
Samira Mubareka,
Jared T. Simpson,
Bettina Hamelin,
Henry Wong,
Leanne Mortimer,
Robert Slinger,
Andrew G. McArthur ,
Marc Desjardins,
Allison McGeer,
Tony Mazzulli,
Katya Douchant,
Danielle Brabant-Kirwan,
Ramzi Fattouh
and other authors.
,
Jennifer L. Guthrie,
Samira Mubareka,
Jared T. Simpson,
Bettina Hamelin,
Henry Wong,
Leanne Mortimer,
Robert Slinger,
Andrew G. McArthur ,
Marc Desjardins,
Allison McGeer,
Tony Mazzulli,
Katya Douchant,
Danielle Brabant-Kirwan,
Ramzi Fattouh
and other authors.
This paper is made freely available by the publisher.
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Abstract
Genome-wide variation in SARS-CoV-2 reveals evolution and transmission dynamics which are critical considerations for disease control and prevention decisions. Here, we review estimates of the genome-wide viral mutation rates, summarize current COVID-19 case load in the province of Ontario, Canada (5 January 2021), and analyze published SARS-CoV-2 genomes from Ontario (collected prior to 24 November 2020) to test for more infectious genetic variants or lineages.