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American Society of Hematology, Blood, 18(138), p. 1773-1777, 2021

DOI: 10.1182/blood.2021011677

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Torque teno mini virus as a cause of childhood acute promyelocytic leukemia lacking PML/RARA fusion

Journal article published in 2021 by Annalisa Astolfi ORCID, Riccardo Masetti ORCID, Valentina Indio ORCID, Salvatore Nicola Bertuccio ORCID, Daria Messelodi ORCID, Simone Rampelli ORCID, Davide Leardini ORCID, Matteo Carella ORCID, Salvatore Serravalle ORCID, Virginia Libri ORCID, Jessica Bandini, Stefano Volinia ORCID, Marco Candela ORCID, Andrea Pession ORCID
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Abstract

Astolf et al provide the first report of acute promyelocytic leukemia driven by viral insertion into the RARA locus. This represents a clear demonstration of a pathology driven by the member of the anelloviruses, a group of viruses otherwise thought to have minimal or no pathogenic potential.