Abstract We compare the radial profiles of the specific star formation rate (sSFR) in a sample of 169 star-forming galaxies in close pairs with those of mass-matched control galaxies in the SDSS-IV MaNGA survey. We find that the sSFR is centrally enhanced (within one effective radius) in interacting galaxies by ∼0.3 dex and that there is a weak sSFR suppression in the outskirts of the galaxies of ∼0.1 dex. We stack the difference profiles for galaxies in five stellar-mass bins in the range log(M/M _⊙) = 9.0–11.5 and find that the sSFR enhancement has no dependence on the stellar mass. The same result is obtained when comparison galaxies are matched to each paired galaxy in both stellar mass and redshift. In addition, we find that the sSFR enhancement is elevated in pairs with nearly equal masses and closer projected separations, in agreement with previous work based on single-fiber spectroscopy. We also find that the sSFR offsets in the outskirts of the paired galaxies are dependent on whether the galaxy is the more-massive or less-massive companion in the pair. The more-massive companion experiences zero to a positive sSFR enhancement, while the less-massive companion experiences sSFR suppression in their outskirts. Our results illustrate the complex tidal effects on star formation in closely paired galaxies.