Abstract We report the discovery of pulsations in the extremely low-mass (ELM), likely helium-core white dwarf GD 278 via ground- and space-based photometry. GD 278 was observed by the Transiting Exoplanet Survey Satellite (TESS) in Sector 18 at a 2 minute cadence for roughly 24 days. The TESS data reveal at least 19 significant periodicities between 2447 and 6729 s, one of which is the longest pulsation period ever detected in a white dwarf. Previous spectroscopy found that this white dwarf is in a 4.61 hr orbit with an unseen >0.4 M _⊙ companion and has T _eff = 9230 ± 100 K and log g = 6.627 ± 0.056 , which corresponds to a mass of 0.191 ± 0.013 M _⊙. Patterns in the TESS pulsation frequencies from rotational splittings appear to reveal a stellar rotation period of roughly 10 hr, making GD 278 the first ELM white dwarf with a measured rotation rate. The patterns inform our mode identification for asteroseismic fits, which, unfortunately, do not reveal a global best-fit solution. Asteroseismology reveals two main solutions roughly consistent with the spectroscopic parameters of this ELM white dwarf, but with vastly different hydrogen-layer masses; future seismic fits could be further improved by using the stellar parallax. GD 278 is now the tenth known pulsating ELM white dwarf; it is only the fifth known to be in a short-period binary, but is the first with extended, space-based photometry.