In this study, the healing process of full-thickness skin wounds induced in Wistar rats (n = 75) was evaluated, divided into 5 treatments: negative control, PVA nanofiber film, and PVA nanofiber film added in concentrations of 3%, 6% and 10% with lyophilized extract of T. catappa. After euthanasia of 5 animals from each of the groups, at times 7, 14 and 21 days, samples were evaluated for the presence of oxidative stress markers reduced Glutathione (GSH) and levels of lipoperoxidation (LPO), and for the histological characteristics of tissues stained with hematoxylin-eosin and azan. The results showed that, in addition to remaining on the surface of the wounds for an acceptable period, the nanofiber membrane was able to deliver the extract of T. catappa to the bed of the treated wounds and, despite not producing statistically relevant histological changes, it was observed significant antioxidant effect by reducing LPO and increasing GSH in a dose dependent manner. Thus, it is concluded that the PVA nanofiber film associated with the T. catappa extract has an antioxidant effect and can assist in wound healing