Published in
American Society for Microbiology, Microbiology Spectrum, 4(10), 2022
DOI: 10.1128/spectrum.00674-22
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Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing
Journal article published in 2022 by
Francisco Olivença 
,
Alexandra Nunes ,
Rita Macedo ,
David Pires ,
Cátia Silveiro ,
Elsa Anes ,
Maria Miragaia ,
João Paulo Gomes ,
Maria João Catalão
,
Alexandra Nunes ,
Rita Macedo ,
David Pires ,
Cátia Silveiro ,
Elsa Anes ,
Maria Miragaia ,
João Paulo Gomes ,
Maria João Catalão
This paper is made freely available by the publisher.
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Abstract
Associations between differential M. tuberculosis beta-lactam phenotypes and preexisting antimycobacterial drug resistance, strain sublineage, or specific mutational patterns were established. Importantly, we reveal that highly drug-resistant isolates of sublineage 4.3.4.2 have an increased susceptibility to beta-lactams compared with other strains.