Weathering of bedrock to produce regolith is essential for sustaining life on Earth and global biogeochemical cycles. The rate of this process is influenced not only by tectonics, but also by climate and biota. We present new data on soil production, chemical weathering, and physical erosion rates from the large climate and ecological gradient of the Chilean Coastal Cordillera (26 to 38∘ S). Four Chilean study areas are investigated and span (from north to south) arid (Pan de Azúcar), semi-arid (Santa Gracia), Mediterranean (La Campana), and temperate humid (Nahuelbuta) climate zones. Observed soil production rates in granitoid soil-mantled hillslopes range from ∼7 to 290 t km−2 yr−1 and are lowest in the sparsely vegetated and arid north and highest in the Mediterranean setting. Calculated chemical weathering rates range from zero in the arid north to a high of 211 t km−2 yr−1 in the Mediterranean zone. Chemical weathering rates are moderate in the semi-arid and temperate humid zones (∼20 to 50 t km−2 yr−1). Similarly, physical erosion rates are lowest in the arid zone (∼11 t km−2 yr−1) and highest in the Mediterranean climate zone (∼91 t km−2 yr−1). The contribution of chemical weathering to total denudation rates is lower in the arid north than further south. However, due to heterogeneities in lithologies and Zr concentrations, reported chemical weathering rates and chemical depletion fractions are affected by large uncertainties. Comparison of Chilean results to published global data collected from hillslope settings underlain by granitoid lithologies documents similar patterns in soil production, chemical weathering, and total denudation rates for varying mean annual precipitation and vegetation cover amounts. We discuss the Chilean and global data in the light of contending model frameworks in the literature and find that observed variations in soil production rates bear the closest resemblance to models explicitly accounting for variations in soil thickness and biomass.