Land use and cover (LUC) of southern European mountains is dramatically changing, mainly due to observed socioeconomic demands and climatic changes. It is therefore important to understand LUC changes to accurately predict future landscapes and their threats. Simulation models of LUC change are ideal for this task because they allow the in silico experimentation under different socioeconomic and climatic scenarios. In the present study, we employed the trans-CLUE-S model, to predict for 2055 the LUC of a typical southern European sub-mountainous area, which has experienced widespread abandonment until recently. Four demand scenarios were tested, and under each demand scenario, we compared three climatic scenarios, ranging from less to more warm and dry conditions. We found that farmland declined from 3.2% of the landscape in 2015 to 0.4% in 2055 under the business-as-usual demand scenario, whereas forest further increased from 62.6% to 79%. For any demand scenario, differences in LUC between maps predicted under different climatic scenarios constituted less than 10% of the landscape. In the less than 10% that differed, mainly farmland and forest shifted to higher elevation under a warmer and drier climate, whereas grassland and scrubland to lower. Such insights by modelling analyses like the present study’s can improve the planning and implementation of management and restoration policies which will attempt to conserve ecosystem services and mitigate the negative effects of socioeconomic and climatic changes in the mountainous regions of southern Europe.