Wiley, Journal of Surgical Oncology, 2(126), p. 365-371, 2022
DOI: 10.1002/jso.26867
Full text: Unavailable
AbstractIntroductionPrimary abdominal wall sarcomas are rare, heterogeneous tumours. The mainstay of management is surgery, although local recurrences (LR) and distant metastases (DM) are common.ObjectivesOverall survival (OS) and disease‐free survival (DFS) were primary outcomes; factors associated with prognosis secondary outcomes.Materials and MethodsPatients undergoing surgery of primary abdominal wall sarcomas between April 2008 and May 2018 were identified at two referrals centres for sarcoma surgery. Patient demographics, tumour and treatment‐related characteristics were recorded and analysed.ResultsA cohort of 65 patients underwent surgical resection with a median follow‐up of 56 months, 5‐year OS and DFS were 69% and 71%, respectively. Eleven patients (16.9%) experienced a recurrence event: 6 LR (9.2%), 10 DM (15.4%) and 5 both (7.7%). At univariate analysis, size (p = 0.03), grade (p = 0.001) and depth (p = 0.04) were associated with OS while size (p = 0.02) was associated with DFS. No significant relationship with tumour depth, type of surgery, surgical margin status or neo‐/adjuvant treatment was demonstrated.ConclusionRecurrence events are less common following treatment of abdominal wall sarcomas if compared to extremities STSs, but size (≥5 cm), high malignancy grade (FNCLCC 3) and depth are associated with worse OS.