Abstract The Gas Pixel Detector is a gas detector, sensitive to the polarization of X-rays, currently flying onboard the Imaging X-ray Polarimetry Explorer (IXPE)—the first observatory dedicated to X-ray polarimetry. It detects X-rays and their polarization by imaging the ionization tracks generated by photoelectrons absorbed in the sensitive volume, and then reconstructing the initial direction of the photoelectrons. The primary ionization charge is multiplied and ultimately collected on a finely pixellated ASIC specifically developed for X-ray polarimetry. The signal of individual pixels is processed independently and gain variations can be substantial, of the order of 20%. Such variations need to be equalized to correctly reconstruct the track shape, and therefore its polarization direction. The method to do such equalization is presented here and is based on the comparison between the mean charge of a pixel with respect to the other pixels for equivalent events. The method is shown to finely equalize the response of the detectors onboard IXPE, allowing a better track reconstruction and energy resolution, and can in principle be applied to any imaging detector based on tracks.