Acute: chronic workload ratio (ACWR) and training monotony have been criticized as injury risk predictors. Therefore, the use of intensity measures should be oriented to understand the variations of intensity across the season. The aim of this systematic review is to summarize the main evidence about the ACWR and training monotony variations over the season in professional soccer players. The search was made in PubMed, SPORTDiscus, and FECYT according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. From the 225 studies initially identified, 27 were fully reviewed, and their outcome measures were extracted and analyzed. Existing literature revealed a variety of designs, ACWR and training monotony ranges, variables assessed and durations of the studies. Overall, the range values for ACWR were 0.4–3.39 AU, while those focused on monotony were 0.49–5.7 AU. Regarding ACWR, the ratios located around 0.85–1.25 could predict lower risk values and ratios around ≥1.50 could predict higher risk values. On the contrary, with respect to training monotony, the ratios are approximately between 0.5 and 2.00 (low values in the preseason and low competition weeks and high values when soccer players are in highly scheduled competition weeks). Nevertheless, ACWR and training monotony methods should be addressed and considered based on their real value before using this indicator to reduce injury risk. In fact, the data did not conclusively define injured and non-injured players. For this reason, utilizing standardized approaches will allow for more precise conclusions about professional soccer players.